Olanzapine in the treatment of depressive disorders with psychotic symptoms

We report on the successful treatment of two female patients with psychotic depression with the new atypical neuroleptic drug olanzapine. A 75-year-ol d female in patient suffering from recurrent endogenous depression with tac tile hallucinations and co-enesthesia was refractory to a systematic sequen tial antidepressant treatment strategy during a 39-week period. After addit ion of the new atypical neuroleptic olanzapine to the SSRI citalopram, she showed immediate and ongoing symptom relief. In the second case of a 57-yea r-old female inpatient suffering from delusional depression,we observed mar ked symptom relief and correction of the delusions of impoverishment. Olanz apine is discussed with regard to its receptor-binding profile (antagonism to 5-HT2A- and D1-D4 receptors) as a potential neuroleptic drug in the trea tment of affective disorders with psychotic symptoms.