HAART improves prognosis in HIV-associated progressive multifocal leukoencephalopathy

Authors
Clifford, DB Yiannoutsos, C Glicksman, M Simpson, DM Singer, EJ Piliero, PJ Marra, CM Francis, GS McArthur, JC Tyler, KL Tselis, AC Hyslop, NE
Citation
Db. Clifford et al., HAART improves prognosis in HIV-associated progressive multifocal leukoencephalopathy, NEUROLOGY, 52(3), 1999, pp. 623-625
Citations number
10
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
NEUROLOGY
ISSN journal
00283878 → ACNP
Volume
52
Issue
3
Year of publication
1999
Pages
623 - 625
Database
ISI
SICI code
0028-3878(199902)52:3<623:HIPIHP>2.0.ZU;2-G
Abstract
Introduction of highly active antiretroviral therapy (HAART) has been assoc iated with many changes in the complications of human immunodeficiency viru s (HIV) infection. A cohort of 25 HIV patients with progressive multifocal leukoencephalopathy (PML) treated with HAART experienced a median survival of >46 weeks. This is an improvement in prognosis compared with recent hist oric experience and correlated with HIV RNA viral load reductions. We concl ude that current HIV therapy is important in improving the outlook of PML i n the setting of HIV.