Alternative to endoscopic sinus surgery in the management of pediatric chronic rhinosinusitis refractory to oral antimicrobial therapy

We determined the safety, feasibility, and efficacy of a treatment regimen consisting of maxillary sinus aspiration and irrigation with or without ade noidectomy, followed by culture-directed intravenous antibiotics and oral p rophylaxis, for children with chronic rhinosinusitis refractory to oral ant imicrobial therapy, Twenty-seven children (age 1-12 years, mean 6.7 years) with symptomatic (mean duration 16 months) and computed tomography-proven s inus disease, which persisted despite at least 1 month of oral antibiotics, were treated. Twenty-four patients (89%) had complete resolution of their presenting symptoms after intravenous therapy; in 3 (11%), intravenous ther apy failed and endoscopic sinus surgery was required. Follow-up data were a vailable for 26 of the children (96%); 23 of them had initial complete reso lution. At last follow-up (mean 282 days, range 26-1095 days), 10 of these 23 patients (44%) remained asymptomatic, and 13 (57%) had had at least one other episode of sinusitis (mean 1.0, range 1-3) treated with oral antibiot ics, with resolution. Treatment-related complications included superficial thrombophlebitis (7%), diarrhea (7%), intravenous catheter guide-wire kink requiring venotomy (4%), and serum sickness-like syndrome (4%). These preli minary results suggest that this treatment plan is relatively safe and feas ible and that it may be a reasonable alternative to endoscopic sinus surger y in children with chronic rhinosinusitis unresponsive to orally administer ed antimicrobial therapy.