Primary ovarian angiosarcoma: A case report and literature review

Primary ovarian angiosarcoma is extremely rare. Only 16 cases have histolog ically been reported to date in the literature. A case of angiosarcoma aris ing in the right ovary of a 48-year-old female Is presented. Grossly, the r esected right ovary was completely replaced by a solid tumor mass, which re vealed multiple necrotic and/or hemorrhagic foci. This case revealed the ty pical histological features of angiosarcoma with sinusoidal and solid patte rns of anaplastic tumor cells. Immunohistochemically, tumor cells were stro ngly and diffusely positive for CD31 and CD34, in particular, along the cyt oplasmic membrane of the tumor cells. Ultrastructurally, tumor cells posses sed the intermediate junctions between tumor cells, discontinuous basal lam inae attached to the irregularly shaped blood vessels and occasional cytopl asmic pinocytotic vesicles. These findings confirmed the case as being one of angiosarcoma of the ovary. The patient died 9 months after surgery as a result of developed multifocal brain metastases. A total of 17 cases report ed as primary ovarian angiosarcoma, including this presented case, are clin icopathologically reviewed.