Pregnancy outcomes after maternal exposure to fluconazole

We evaluated pregnancy outcomes in 234 women exposed to fluconazole, 492 ex posed to a topically administered azole preparation, 88 exposed to an oral azole preparation other than fluconazole, and 1629 not exposed to any of th ese agents during the first trimester of pregnancy. Relative risks of havin g a baby with a congenital disorder for women exposed to fluconazole, oral azoles, and topical azoles in the first trimester of pregnancy compared wit h those who were unexposed were 1.1 (95% CI 0.4-3.3), 2.1 (95% CI 0.7-6.8), and 0.6 (95% CI 0.2-1.6), respectively These results provide reassurance t hat fluconazole exposure in the first trimester of pregnancy does not mater ially increase the risk of congenital disorders in infants.