Suspected carbamazepine-induced hepatotoxicity

Carbamazepine is a potent anticonvulsant agent with proven efficacy in the treatment of partial and tonic-clonic seizures. An epileptic child treated with therapeutic dosages of carbamazepine developed severe hepatitis and he patic insufficiency. She had a positive response to withdrawal of the drug and administration of corticosteroids. The Roussel UCLAF method for estimat ing causality of the adverse event was applied for an acute hepatocellular problem, with a final score of 8. This method has advantages over other too ls because it involves many clinical factors that give additional guides to clinicians in patients with liver injury, but it must be adapted for adver se events in the pediatric population.