Acyl-CoA : cholesterol acyltransferase inhibitory activity of lignans isolated from Schizandra, Machilus and Magnolia species

Authors
Kwon, BM Jung, HJ Lim, JH Kim, YS Kim, MK Kim, YK Bok, SH Bae, KH Lee, IR
Citation
Bm. Kwon et al., Acyl-CoA : cholesterol acyltransferase inhibitory activity of lignans isolated from Schizandra, Machilus and Magnolia species, PLANTA MED, 65(1), 1999, pp. 74-76
Citations number
17
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PLANTA MEDICA
ISSN journal
00320943 → ACNP
Volume
65
Issue
1
Year of publication
1999
Pages
74 - 76
Database
ISI
SICI code
0032-0943(199902)65:1<74:A:CAIA>2.0.ZU;2-1
Abstract
Fifteen lignans were isolated from the fruits of Schizandra chinensis, the leaves of Machilus thunbergii, and the flower buds of Magnolia denudata. Th ey were identified as gomisins, schizandrin, wuweizisu, schizantherin, lica rins, and machilin, which inhibited rat liver ACAT with IC50 values of 25 - 200 mu M. Gomisin N is the most potent inhibitor with IC50 value of 25 mu M in these lignans.