Background. Recent studies have suggested that subjects with depression suf
fer a diagnosis-specific motivational deficit,. characterized by an abnorma
l response to negative feedback that endures beyond clinical recovery. Furt
hermore, it has been suggested that negative feedback may motivate non-depr
essed controls, but not depressed patients, to improve their performance in
neuropsychological tests.
Methods. We describe two studies. The first compared performance on the sim
ultaneous and delayed match to sample (SDMS) task from the CANTAB neuropsyc
hological test battery, in 20 patients with severe depression with 20 with
acute schizophrenia, 40 with chronic schizophrenia and 40 healthy controls.
The second examined the performance of depressed patients with diurnal var
iation in symptoms and cognitive function.
Results. All patients groups showed impairments on the simultaneous and del
ayed match to sample task compared to controls. Depressed patients did not
show an abnormal response to negative feedback. Controls did not show a mot
ivational effect of negative feedback. Depressed patients with diurnal vari
ation showed no variation in their response to perceived failure. There was
no evidence of abnormal response to negative feedback in any patient group
using the 'runs test' or of a motivational effect in controls. Conditional
probability analysis was not independent of the total number of errors mad
e in the SDMS task.
Conclusions. Further studies are suggested to examine whether an abnormal r
esponse to negative feedback characterizes particular subgroups of patients
suffering from depression.