Changes on the temperament and character inventory after paroxetine treatment in volunteers with generalized anxiety disorder

Previously untreated symptomatic volunteers with generalized anxiety disord er (GAD) performed the Temperament and Character Inventory at baseline and after 4 to 6 months of paroxetine treatment. Scores from 29 volunteers were analyzed with paired t-tests. A marked reduction was noted in Harm Avoidan ce and a marked increase was noted in Self-Directedness. Smaller changes we re noted in Cooperativeness and Novelty Seeking. Overall, treatment was ass ociated with a reduction in maladaptive personality traits.