Optically active 3-amino-3-pyrrolidones by reductive N-N-bond cleavage of 1-pyrazolines derived from (R)-3-hydroxybutyric acid

Authors
Bartels, A Liebscher, J
Citation
A. Bartels et J. Liebscher, Optically active 3-amino-3-pyrrolidones by reductive N-N-bond cleavage of 1-pyrazolines derived from (R)-3-hydroxybutyric acid, SYN COMMUN, 29(2), 1999, pp. 193-199
Citations number
13
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNTHETIC COMMUNICATIONS
ISSN journal
00397911 → ACNP
Volume
29
Issue
2
Year of publication
1999
Pages
193 - 199
Database
ISI
SICI code
0039-7911(1999)29:2<193:OA3BRN>2.0.ZU;2-#
Abstract
Raney-Ni-catalyzed hydrogenation of 1-pyrazoline-3-carboxylic acid derivati ves 3 affords optically active 4-substituted trans-3-amino-2-pyrrolidones 6 as new unnatural alpha,gamma-diaminoacid derivatives by reductive N-N-bond cleavage, ring transformation and retro-aldol reaction.