Simple synthesis of enantiomerically pure C-2-symmetric bisoxazolidines from amino alcohols and formaldehyde

Authors
Bolm, C Chuang, TH Raabe, G Fang, JM
Citation
C. Bolm et al., Simple synthesis of enantiomerically pure C-2-symmetric bisoxazolidines from amino alcohols and formaldehyde, SYN COMMUN, 29(1), 1999, pp. 43-51
Citations number
28
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNTHETIC COMMUNICATIONS
ISSN journal
00397911 → ACNP
Volume
29
Issue
1
Year of publication
1999
Pages
43 - 51
Database
ISI
SICI code
0039-7911(1999)29:1<43:SSOEPC>2.0.ZU;2-6
Abstract
Treatment of chiral amino alcohols 1 with an excess of formaldehyde followe d by reaction with NaOH at room temperature provides optically active C-2-s ymmetric N,N'-methylenebisoxazolidines 2 in high yield.