FMOC-peptide acid chlorides in fragment coupling: Synthesis of beta-casomorphin by 3+2 divergent approach

Authors
Babu, VVS Gayathri, K Gopi, HN
Citation
Vvs. Babu et al., FMOC-peptide acid chlorides in fragment coupling: Synthesis of beta-casomorphin by 3+2 divergent approach, SYN COMMUN, 29(1), 1999, pp. 79-91
Citations number
17
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNTHETIC COMMUNICATIONS
ISSN journal
00397911 → ACNP
Volume
29
Issue
1
Year of publication
1999
Pages
79 - 91
Database
ISI
SICI code
0039-7911(1999)29:1<79:FACIFC>2.0.ZU;2-V
Abstract
Fmoc-peptide acid chlorides are prepared and used as rapid and efficient co upling agents in fragment coupling. Thus the synthesis of the model tetrape ptide Leu-Ala-Gly-Val and beta-casomorhin (Tyr-Pro-Phe-Pro-Gly) are accompl ished by the (2+2) and (3+2) divergent approach respectively.