New submonomers for poly N-substituted glycines (peptoids)

Five protected submonomers for peptoid synthesis were prepared, including N -in-BOC-tryptamine, O-t-butyl tyramine, PMC-guanidino-propylamine, 6-amino- 6-deoxy-D-galactopyranose diacetonide, and 5-amino-2,2-dimethyl-1,3-dioxane . The first three mimic natural aminoacid sidechains i.e, tryptophan, tyros ine, and arginine, while the last two provide hydrophilic sidechains. These submonomers were successfully used for preparation of oligo-peptoids by th e submonomer synthesis method. (C) 1999 Elsevier Science Ltd. All rights re served.