A new strategy for regioselective interstrand disulfide bridging of multiple cysteine peptides

Authors
Ottl, J Moroder, L
Citation
J. Ottl et L. Moroder, A new strategy for regioselective interstrand disulfide bridging of multiple cysteine peptides, TETRAHEDR L, 40(8), 1999, pp. 1487-1490
Citations number
20
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
8
Year of publication
1999
Pages
1487 - 1490
Database
ISI
SICI code
0040-4039(19990219)40:8<1487:ANSFRI>2.0.ZU;2-Q
Abstract
Based on existing methods in cysteine chemistry a new strategy is described for repeating regioselective interstrand disulfide bridging of multiple cy steine peptides into heteromeric constructs crosslinked by a ladder of disu lfides. The efficacy of this new approach is demonstrated by the successful assembly of three different collagenous peptides into heterotrimers in the defined alpha 1/alpha 2/alpha 1' order. (C) 1999 Elsevier Science Ltd. All rights reserved.