Integrating computer prediction systems with in vitro methods towards a better understanding of toxicology

Structure Activity Relationships (SARs) or Quantitative Structure Activity Relationships (QSARs) form the basis of most computer prediction systems in toxicology. The underlying premise of SARs and QSARs is that the propertie s of a chemical are implicit in its molecular structure. For an SAR or QSAR to be valid and reliable, the dependent property for all of the chemicals covered by the relationship has to be elicited by a mechanism which is both common to the set of chemicals as well as relevant to that dependent prope rty. Similar principles must also be applied to the development of in vitro alternatives to animal tests if those methods are to be reliable. A number of ways in which computer prediction systems and in vitro toxicology can c omplement each other in the development of alternatives to live animal expe riments are described. (C) 1998 Elsevier Science Ireland Ltd. All rights re served.