Intranasal or subcutaneous co-administration of recombinant cholera toxin B subunit stimulates only a slight or no level or the specific IgE responsein mice to tetanus toxoid

Citation
M. Isaka et al., Intranasal or subcutaneous co-administration of recombinant cholera toxin B subunit stimulates only a slight or no level or the specific IgE responsein mice to tetanus toxoid, VACCINE, 17(7-8), 1999, pp. 944-948
Citations number
28
Categorie Soggetti
Veterinary Medicine/Animal Health",Immunology
Journal title
VACCINE
ISSN journal
0264410X → ACNP
Volume
17
Issue
7-8
Year of publication
1999
Pages
944 - 948
Database
ISI
SICI code
0264-410X(19990226)17:7-8<944:IOSCOR>2.0.ZU;2-6
Abstract
Whether recombinant cholera toxin B subunit (rCTB) co-administered intranas ally or subcutaneously with aluminium-nonadsorbed tetanus toroid (nTT) can induce the production of tetanus toroid mi-specific IgE antibodies in mice was investigated compared with aluminium-adsorbed tetanus toroid (aTT) admi nistered intranasally of subcutaneously. Mice immunized intranasally or sub cutaneously with nTT together with rCTB showed a high level of TT-specific serum IBG antibody response and no or a slight level of TT-specific serum I gE antibody response. On the other hand, in mice vaccinated intranasally or subcutaneously with aTT alone. higher levels of TT-specific IgG and IgE an tibodies were induced in comparison with intranasal or subcutaneous inocula tion of nTT together with rCTB. These results suggest that intranasal or su bcutaneous coadministration of rCTB with nTT is better than intranasal or s ubcutaneous administration or aTT to avoid IgE-mediated allergic reactions. (C) 1999 Elsevier Science Ltd. All rights reserved.