Intranasal or subcutaneous co-administration of recombinant cholera toxin B subunit stimulates only a slight or no level or the specific IgE responsein mice to tetanus toxoid
M. Isaka et al., Intranasal or subcutaneous co-administration of recombinant cholera toxin B subunit stimulates only a slight or no level or the specific IgE responsein mice to tetanus toxoid, VACCINE, 17(7-8), 1999, pp. 944-948
Whether recombinant cholera toxin B subunit (rCTB) co-administered intranas
ally or subcutaneously with aluminium-nonadsorbed tetanus toroid (nTT) can
induce the production of tetanus toroid mi-specific IgE antibodies in mice
was investigated compared with aluminium-adsorbed tetanus toroid (aTT) admi
nistered intranasally of subcutaneously. Mice immunized intranasally or sub
cutaneously with nTT together with rCTB showed a high level of TT-specific
serum IBG antibody response and no or a slight level of TT-specific serum I
gE antibody response. On the other hand, in mice vaccinated intranasally or
subcutaneously with aTT alone. higher levels of TT-specific IgG and IgE an
tibodies were induced in comparison with intranasal or subcutaneous inocula
tion of nTT together with rCTB. These results suggest that intranasal or su
bcutaneous coadministration of rCTB with nTT is better than intranasal or s
ubcutaneous administration or aTT to avoid IgE-mediated allergic reactions.
(C) 1999 Elsevier Science Ltd. All rights reserved.