Adjuvant therapy has shown to be of significant benefit in patients with br
east cancer. Among the possibilities to further improve the results, preope
rative chemotherapy is a promising tool. So far, we have treated 178 patien
ts and found that downstaging permits breast conservation in 60 % of patien
ts who would otherwise undergo mastectomy. The significance of this method
for further improvement of survival has to await results of ongoing trials.