Cyclodextrins in targeting - Application to nanoparticles

For some years cyclodextrins and their hydrophilic derivatives have been de scribed in the Literature as solubilizers capable of enhancing the loading capacity of liposomes and microparticles. We present here two new possibili ties of using cyclodextrins in the design of colloidal carriers. The first possibility consists in increasing the loading capacity of poly(isobutyl cy anoacrylate) nanospheres prepared by anionic polymerization, by employing h ydroxypropyl cyclodextrins. The second possibility consists in the spontane ous formation of either nanocapsules or nanospheres by the nanoprecipitatio n of amphiphilic cyclodextrin diesters. These two new techniques are very p romising because of the great interest presented by nanoparticles for drug administration by the oral or parenteral routes. (C) 1999 Elsevier Science B.V. All rights reserved.