Reduction of blood ethanol levels by the gamma-hydroxybutyric acid receptor antagonist, NCS-382

Authors
Colombo, G Agabio, R Bourguignon, JJ Lobina, C Loche, A Maitre, M Reali, R Gessa, GL
Citation
G. Colombo et al., Reduction of blood ethanol levels by the gamma-hydroxybutyric acid receptor antagonist, NCS-382, ALCOHOL, 17(2), 1999, pp. 93-95
Citations number
13
Categorie Soggetti
Neurosciences & Behavoir
Journal title
ALCOHOL
ISSN journal
07418329 → ACNP
Volume
17
Issue
2
Year of publication
1999
Pages
93 - 95
Database
ISI
SICI code
0741-8329(199902)17:2<93:ROBELB>2.0.ZU;2-G
Abstract
The present study demonstrates that the gamma-hydroxybutyric acid receptor antagonist, NCS-382, markedly reduces blood ethanol levels (BELs) in rats w hen ethanol is administered via the intragastric route, whereas it is compl etely ineffective when ethanol is injected IF. The reducing effect of NCS-3 82 on BELs is likely due to a lessened absorption of ethanol from the gastr ointestinal tract. (C) 1999 Elsevier Science Inc. All rights reserved.