H. Pilegaard et al., Effect of high-intensity exercise training on lactate/H+ transport capacity in human skeletal muscle, AM J P-ENDO, 39(2), 1999, pp. E255-E261
Citations number
36
Categorie Soggetti
Endocrinology, Nutrition & Metabolism
Journal title
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
The present study examined the effect of high-intensity exercise training o
n muscle sarcolemmal lactate/H+ transport and the monocarboxylate transport
ers (MCT1 and MCT4) as well as lactate and H+ release during intense exerci
se in humans. One-legged knee-extensor exercise training was performed for
8 wk, and biopsies were obtained from untrained and trained vastus laterali
s muscle. The rate of lactate/H+ transport determined in sarcolemmal giant
vesicles was 12% higher (P < 0.05) in the trained than in untrained muscle
(n = 7). The content of MCT1 and MCT4 protein was also higher (76 and 32%,
respectively; n = 4) in trained muscle. Release of lactate and H+ from the
quadriceps muscle at the end of intense exhaustive knee-extensor exercise w
as similar in the trained and untrained leg, although the estimated muscle
intracellular-to-interstitial gradients of lactate and Hf were lower (P < 0
.05) in the trained than in the untrained muscle. The present data show tha
t intense exercise training can increase lactate/H+ transport capacity in h
uman skeletal muscle as well as improve the ability of the muscle to releas
e lactate and H+ during contractions.