The porcine hormone-sensitive lipase gene: sequence, structure, polymorphisms and linkage mapping

Authors
Harbitz, I Langset, M Ege, AG Hoyheim, B Davies, W
Citation
I. Harbitz et al., The porcine hormone-sensitive lipase gene: sequence, structure, polymorphisms and linkage mapping, ANIM GENET, 30(1), 1999, pp. 10-15
Citations number
20
Categorie Soggetti
Animal Sciences","Molecular Biology & Genetics
Journal title
ANIMAL GENETICS
ISSN journal
02689146 → ACNP
Volume
30
Issue
1
Year of publication
1999
Pages
10 - 15
Database
ISI
SICI code
0268-9146(199902)30:1<10:TPHLGS>2.0.ZU;2-S
Abstract
The porcine hormone-sensitive lipase gene and its cDNA have been isolated a nd sequenced. Several putative regulatory sequences have been detected in t he promotor region. The deduced amino acid sequence is 85% identical to the corresponding human, mouse and rat sequence. A search for polymorphisms re vealed one intronic and one exonic polymorphism, the latter resulting in a conservative amino acid substitution. Linkage mapping located the LIFE gene close to the calcium release channel (CRC) locus on chromosome 6.