Synthesis, toxicological, and pharmacological assessment of derivatives of2-aryl-4-(3-arylpropyl)morpholines

The synthesis of nine original morpholine derivatives, i.e.2-aryl-4-(3-aryl propyl)morpholines, is described. The structure of all synthesised derivati ves was proved by IR and H-1-NMR, and some C-13-NMR. Acute toxicity studies of the compounds of them by were performed on mice. A comparative pharmaco logical study of the in vivo effects on the central nervous system was unde rtaken using the screening tests: hexobarbital induced sleeping time; locom otor activity; and behaviour despair (for antidepressive activity). The mos t active compound 4-(2-benzoylethyl)-2-phenyl-3-methyl) morpholine 4e was s tudied for MAO-A and MAO-B inhibition in vitro in rat brain mitochondria pr eparations.