fMLP-OMe analogs substituted at the methionine residue: An insight into the receptor properties

Authors
Cavicchioni, G Monesi, LG Ferretti, ME Fabbri, E Rizzuti, O Spisani, S
Citation
G. Cavicchioni et al., fMLP-OMe analogs substituted at the methionine residue: An insight into the receptor properties, ARCH PHARM, 331(11), 1998, pp. 368-370
Citations number
10
Categorie Soggetti
Pharmacology & Toxicology
Journal title
ARCHIV DER PHARMAZIE
ISSN journal
03656233 → ACNP
Volume
331
Issue
11
Year of publication
1998
Pages
368 - 370
Database
ISI
SICI code
0365-6233(199811)331:11<368:FASATM>2.0.ZU;2-N
Abstract
In order to obtain an insight into the mode of binding at the for-Met-Leu-P he-OH (fMLP) receptor, three fMLP-OMe analogs (1-3) were synthesized in whi ch the Met residue was substituted by Gin 1, Asn 2, and Ser 3. We evaluated the influence of the charge variation and/or the shift of its position on neutrophil biological responses.