The adenovirus that causes hemorrhagic disease of black-tailed deer is closely related to bovine adenovirus-3 - Brief report

DNA sequence data was obtained from an adenovirus previously shown to be th e cause of a distinctive, fatal hemorrhagic disease of black-tailed deer in California. A 256 base fragment of the viral hexon gene was amplified by P CR from purified adenovirus preparations. The amplicon then was cloned and sequenced. Phylogenetic relationships with other mammalian adenoviruses wer e also determined. Although sequence analysis of this portion of the hexon gene indicates that the black-tailed deer adenovirus is closely related to bovine adenovirus-3, the biologic properties of the two viruses are clearly distinct.