Effect of transport and competition on ligand binding

Citation
Ca. Condat et al., Effect of transport and competition on ligand binding, BIOPHYS CH, 76(3), 1999, pp. 185-198
Citations number
25
Categorie Soggetti
Biochemistry & Biophysics","Physical Chemistry/Chemical Physics
Journal title
BIOPHYSICAL CHEMISTRY
ISSN journal
03014622 → ACNP
Volume
76
Issue
3
Year of publication
1999
Pages
185 - 198
Database
ISI
SICI code
0301-4622(19990222)76:3<185:EOTACO>2.0.ZU;2-U
Abstract
We present a model to describe the physics of chemoreception in processes d etermined by competitive ligand binding. Our model describes the competitio n between various populations, such as ligands vs. blockers and receptors v s, decoys, in protein activation when diffusion is rate-determining. Full s patio-temporal solutions can be obtained numerically. The model structure i s kept simple enough as to permit its easy generalization to describe a lar ge subset of the manifold of possible situations occurring in nature. The p ower and simplicity of the proposed method are exhibited through the soluti on of several examples which are discussed in detail. (C) 1999 Elsevier Sci ence B.V. All rights reserved.