Protective effects of the TNF-ceramide pathway against glutamate neurotoxicity on cultured mesencephalic neurons

Authors
Shinpo, K Kikuchi, S Moriwaka, F Tashiro, K
Citation
K. Shinpo et al., Protective effects of the TNF-ceramide pathway against glutamate neurotoxicity on cultured mesencephalic neurons, BRAIN RES, 819(1-2), 1999, pp. 170-173
Citations number
21
Categorie Soggetti
Neurosciences & Behavoir
Journal title
BRAIN RESEARCH
ISSN journal
00068993 → ACNP
Volume
819
Issue
1-2
Year of publication
1999
Pages
170 - 173
Database
ISI
SICI code
0006-8993(19990220)819:1-2<170:PEOTTP>2.0.ZU;2-Z
Abstract
Pretreatments with TNF-alpha and lower concentrations of C-2-ceramide prote cted cultured mesencephalic neurons from excitotoxicity in a dose-dependent manner. These protective effects are reduced by cotreatment with N, N-dime thylsphingosine (DMS), an inhibitor of sphingosine kinase. Since the pretre atment with sphingosine-1-phosphate (SPP) showed a neuroprotective effect o ur data suggest that protective effects of TNF and C-2-ceramide could be at tributable to their further metabolism to SPP. (C) 1999 Elsevier Science B. V. All rights reserved.