R. O'Hare et al., Bolus dose remifentanil for control of haemodynamic response to tracheal intubation during rapid sequence induction of anaesthesia, BR J ANAEST, 82(2), 1999, pp. 283-285
Citations number
6
Categorie Soggetti
Aneshtesia & Intensive Care","Medical Research Diagnosis & Treatment
The effect of three bolus doses of remifentanil on the presser response to
laryngoscopy and tracheal intubation during rapid sequence induction of ana
esthesia was assessed in a randomized, double-blind, placebo-controlled stu
dy in four groups of 20 patients each. After preoxygenation, anaesthesia wa
s induced with thiopental 5-7 mg kg(-1) followed immediately by saline (pla
cebo) or remifentanil 0.5, 1.0 or 1.25 mu g kg(-1) given as a bolus over 30
s. Cricoid pressure was applied just after loss of consciousness. Succinyl
choline 1 mg kg(-1) was given for neuromuscular block. Laryngoscopy and tra
cheal intubation were performed 1 min later. Arterial pressure and heart ra
te were recorded at intervals until 5 min after intubation. Remifentanil 0.
5 mu g kg(-1) was ineffective in controlling the increase in heart rate and
arterial pressure after intubation but the 1.0 and 1.25 mu g kg(-1) doses
were effective in controlling the response. The use of the 1.25 mu g kg(-1)
dose was however, associated with a decrease in systolic arterial pressure
to less than 90 mm Hg in seven of 20 patients.