Prevalence of BRCA1 and BRCA2 Jewish mutations in Spanish breast cancer patients

Authors
Diez, O Osorio, A Robledo, M Barroso, A Domenech, M Cortes, J Albertos, J Sanz, J Brunet, J SanRoman, JM Alonso, MC Baiget, M Benitez, J
Citation
O. Diez et al., Prevalence of BRCA1 and BRCA2 Jewish mutations in Spanish breast cancer patients, BR J CANC, 79(7-8), 1999, pp. 1302-1303
Citations number
10
Categorie Soggetti
Oncology,"Onconogenesis & Cancer Research
Journal title
BRITISH JOURNAL OF CANCER
ISSN journal
00070920 → ACNP
Volume
79
Issue
7-8
Year of publication
1999
Pages
1302 - 1303
Database
ISI
SICI code
0007-0920(199903)79:7-8<1302:POBABJ>2.0.ZU;2-H
Abstract
We screened the 185delAG and 5382insC (BRCA1) and the 6174delT (BRCA2) muta tion in 298 Spanish women with breast cancer. Two women (one with Sephardic ancestors) presented the 185delAG mutation and the same haplotype reported in Ashkenazim with this mutation. This suggests a common origin of the 185 delAG in both Sephardic and Ashkenazi populations.