Human immunodeficiency virus-associated fever of unknown origin: A study of 70 patients in the United States and review

To characterize the clinical features of human immunodeficiency virus (HIV) -associated fever of unknown origin (FUO) in the United States, we performe d a retrospective analysis of cases that fulfilled specific criteria (publi shed by Durack and Street in 1991) at two medical centers in the United Sta tes between 1992 and 1997, Seventy cases met criteria for HIV-associated FU O; the mean CD4 cell count was 58/mm(3), and the mean duration of fever was 42 days. A cause of FUO was found in 56 of the 70 cases; 43 were of a sing le etiology, and in 13 cases multiple conditions were established. The most common diagnoses were disseminated Mycobacterium avium infection (DMAC; 31 %), Pneumocystis carinii pneumonia (13%), cytomegalovirus infection (11%), disseminated histoplasmosis (7%), and lymphoma (7%). In this United States series, FUO occurs most often in the late stage of HIV infection, individua l cases often have multiple etiologies, and DMAC is the most common diagnos is.