Background: The P1 blood group antigen has been postulated as a protective
host factor against the development of the verotoxin-associated with hemoly
tic uremic syndrome (HUS). Patients and methods: In this study the P1 blood
group antigen in 59 Japanese children with a past history of hemorrhagic c
olitis (HC) was scored with a direct agglutination method using a commercia
l anti PI antibody. Results: The P1 antigen was positive in 4 (21.1%) of 19
patients with a history of postdiarrheal HUS and in 11 (28.0%) of 40 patie
nts with no history. There were no significant differences in the frequency
of the P1 phenotype between the 2 groups (p = 0.629). Conclusion: We concl
uded that the P1 blood group antigen is not a protective factor against the
development of HUS from verotoxin-producing Escherichia coli(VTEC)-infecte
d hemorrhagic colitis in Japanese individuals.