Intracellular signalling: PDK1 - a kinase at the hub of things

Authors
Belham, C Wu, SL Avruch, J
Citation
C. Belham et al., Intracellular signalling: PDK1 - a kinase at the hub of things, CURR BIOL, 9(3), 1999, pp. R93-R96
Citations number
21
Categorie Soggetti
Experimental Biology
Journal title
CURRENT BIOLOGY
ISSN journal
09609822 → ACNP
Volume
9
Issue
3
Year of publication
1999
Pages
R93 - R96
Database
ISI
SICI code
0960-9822(19990211)9:3<R93:ISP-AK>2.0.ZU;2-F
Abstract
Phosphoinositide-dependent kinase 1 (PDK1) is at the hub of many signalling pathways, activating PKB and PKC isoenzymes, as well as p70 S6 kinase and perhaps PKA. PDK1 action is determined by colocalization with substrate and by target site availability, features that may enable it to operate in bot h resting and stimulated cells.