Effectors for the Rho GTPases

The Rho GTPases are simple enzymes with complex roles in regulating cell mo rphology, gene transcription, cell cycle progression, apoptosis and tumour progression. The picture has been further complicated by the steady rise in the number of known Rho GTPases as well as in the number of known regulato rs and target proteins of these GTPases. Recent implications of Rho effecte rs in human disease, however, might give important clues to how specificity is achieved in cell signalling pathways employing Rho GTPases.