The regulation of replication origin activation

At the start of the cell-division programme, proteins must be assembled ont o replication origins to establish competence for initiation of DNA synthes is. At the correct moment, other effecters must then coordinate appropriate firing of the various origins to control entry into and progress through S phase. These processes are key targets of cell-cycle control, and understa nding their regulation will provide a deeper knowledge of the mechanisms co ntrolling cell proliferation.