Ras caught in another affair: the exchange factors for Ral

Authors
Wolthuis, RMF Bos, JL
Citation
Rmf. Wolthuis et Jl. Bos, Ras caught in another affair: the exchange factors for Ral, CUR OP GEN, 9(1), 1999, pp. 112-117
Citations number
60
Categorie Soggetti
Cell & Developmental Biology
Journal title
CURRENT OPINION IN GENETICS & DEVELOPMENT
ISSN journal
0959437X → ACNP
Volume
9
Issue
1
Year of publication
1999
Pages
112 - 117
Database
ISI
SICI code
0959-437X(199902)9:1<112:RCIAAT>2.0.ZU;2-B
Abstract
The Rat guanine nucleotide exchange factors are direct targets of Ras, prov iding a mechanism for Ral activation by extracellular signals, In addition, Ral can be activated by a Ras-independent pathway. Ral guanine nucleotide exchange factors contribute to cellular transformation induced by oncogenic Ras through an Erk-independent mechanism which may involve activation of t ranscription.