Lung surfactant proteins involved in innate immunity

Authors
Eggleton, P Reid, KBM
Citation
P. Eggleton et Kbm. Reid, Lung surfactant proteins involved in innate immunity, CURR OP IM, 11(1), 1999, pp. 28-33
Citations number
36
Categorie Soggetti
Immunology
Journal title
CURRENT OPINION IN IMMUNOLOGY
ISSN journal
09527915 → ACNP
Volume
11
Issue
1
Year of publication
1999
Pages
28 - 33
Database
ISI
SICI code
0952-7915(199902)11:1<28:LSPIII>2.0.ZU;2-U
Abstract
The two lung surfactant collectins, surfactant protein (SP)-A and SP-D, are involved in host defence against infectious and allergenic agents via enha ncement of killing and clearance by macrophages and neutrophils. Recent gen e-knockout, protein engineering and physiological studies have emphasised t he roles that SP-A and SP-D play in acute inflammatory responses.