Role of platelet activating factor on severity of ischemic colitis

Citation
Y. Nagahata et al., Role of platelet activating factor on severity of ischemic colitis, DIS COL REC, 42(2), 1999, pp. 218-224
Citations number
28
Categorie Soggetti
Gastroenerology and Hepatology
Journal title
DISEASES OF THE COLON & RECTUM
ISSN journal
00123706 → ACNP
Volume
42
Issue
2
Year of publication
1999
Pages
218 - 224
Database
ISI
SICI code
0012-3706(199902)42:2<218:ROPAFO>2.0.ZU;2-T
Abstract
PURPOSE: Ischemic colitis develops after a sudden decrease in colonic blood supply and has a variety of clinical manifestations. The aim of this study was to assess the role of platelet activating factor in the pathogenesis o f ischemic colitis with use of the platelet activating factor antagonist TC V-309. METHODS: Rats were randomly divided into four groups. Rats in Group RV underwent ring attachment around the rectum to induce partial obstructio n and ligation of the marginal vessels of the left colon. As control, rats in Group R underwent the ring attachment and rats in Group V underwent the vascular ligation. Rat in Group C underwent sham operation. The effects of TCV-309 on lesion formation in the colon were evaluated. Thiobarbituric aci d reactant level was determined in colonic mucosa, and the incidence and se verity of ischemic lesions were also determined. RESULTS: Lesions of coliti s were frequency observed in Group RV. TCV-309 did not prevent lesion forma tion, nor did it suppress the increase in thiobarbituric acid reactant leve l in Group RV. However, TCV-309 mitigated the severity of the lesion. CONCL USIONS: Partial obstruction of the colon tends to induce ischemic colitis, and additional ischemia completes lesion formation. Platelet activating fac tor may play a role in the progression of ischemic lesions.