Studies on arylfuran derivatives - Part VII. Synthesis and characterization of some Mannich bases carrying halophenylfuryl moieties as promising antibacterial agents

A series of 4-[5-(halophenyl)-2-furfurylidene)]amino-3-mercapto-5-substitut ed-1,2,4-triazoles (3) were synthesized. Aminomethylation of 3 with formald ehyde and a secondary amine furnished Mannich bases, 4. Both Schiff bases a nd Mannich bases were characterized on the basis of IR, NMR, mass spectral data and elemental analysis. All the newly synthesized compounds were teste d for their antibacterial activities. Some of them carrying morpholino and N-methylpiperazino residues were found to be promising antibacterial agents . (C) 1998 Elsevier Science S.A. All rights reserved.