Preparation of new 5-aroylamino substituted 3-nicotinoyl/isonicotinoyl-1,3,4-thiadiazol-2(3H)-ones with anti-inflammatory activity

Authors
Schenone, S Bruno, O Ranise, A Bondavalli, F Filippelli, W Falcone, G Piucci, B Sorrentino, S
Citation
S. Schenone et al., Preparation of new 5-aroylamino substituted 3-nicotinoyl/isonicotinoyl-1,3,4-thiadiazol-2(3H)-ones with anti-inflammatory activity, FARMACO, 53(8-9), 1998, pp. 586-589
Citations number
16
Categorie Soggetti
Pharmacology & Toxicology
Journal title
FARMACO
ISSN journal
0014827X → ACNP
Volume
53
Issue
8-9
Year of publication
1998
Pages
586 - 589
Database
ISI
SICI code
0014-827X(199808/09)53:8-9<586:PON5S3>2.0.ZU;2-R
Abstract
A series of 1,3,4-thiadiazol-2(3H)-ones (2a-j) with a nicotinoyl/isonicotin oyl group in position 3 and an aroylamino substituent in position 5 of the ring was prepared and evaluated for antipyretic and anti-inflammatory activ ities. All the title compounds and in particular 2e, 2i and 2j exhibited an ti-inflammatory activity and were devoid of antipyretic properties. (C) 199 8 Elsevier Science S.A. All rights reserved.