A SIMPLE AND EFFICIENT SYNTHETIC METHOD FOR FLUORINE-CONTAINING BENZO[H]QUINOLINES

Authors
OKADA E TONE H TSUKUSHI N OTSUKI Y TAKEUCHI H HOJO M
Citation
E. Okada et al., A SIMPLE AND EFFICIENT SYNTHETIC METHOD FOR FLUORINE-CONTAINING BENZO[H]QUINOLINES, Heterocycles, 45(2), 1997, pp. 339-346
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
45
Issue
2
Year of publication
1997
Pages
339 - 346
Database
ISI
SICI code
0385-5414(1997)45:2<339:ASAESM>2.0.ZU;2-2
Abstract
Propargyl-2,4-bis(trifluoroacetyl)-1-naphthylamine (2), prepared from -dimethyl-2,4-bis(trifluoroacetyl)-1-naphthylamine (1) and propargylam ine, undergoes ring forming reaction with amines, thiolates and alcoho lates under mild conditions to afford the corresponding ifluoroacetyl- 4-trifluoro-methylbenzo[h]quinolines (3) in excellent yields.