Refined mapping of the gene for autosomal dominant retinitis pigmentosa (RP17) on chromosome 17q22

Linkage analysis was performed on a large Dutch family with autosomal domin ant retinitis pigmentosa, Linkage was found to the RP17 locus on chromosome 17q22, which was previously described in two South African families by Bar dien et al. (1995, 1997). Assuming that the disease phenotypes in these fam ilies are caused by the same gene, the RP17 critical region is refined to a 7.7-cM interval between markers D17S1607 and D17S948. Two positional candi date genes, the retina-specific amine oxidase (RAO) gene (AOC2) and the con e transducin gamma gene (GNGT2), were excluded.