Analysis of microsatellite instability in cervical cancer

Microsatellite instability was first reported in hereditary nonpolyposis co lorectal cancer (HNPCC) as well as other cancers, including endometrial and ovarian cancers. Single base repeat markers of human MSH3 and MSH6 genes w ere found to precipitate the action of human MSH2. The marker BAT-26 was re ported to be a simple, low-cost, and rapid marker for detection replication errors (RER) and the status of colorectal cancers. We analyzed di-nucleoti de repeats of the microsatellite markers (D2S123, D5S82, D5S299, D10S197, D 17S791, D18S34), single base repeat markers (Delta P-3, hMSH3, hMSH6, and T GF beta-RII), and BAT-26 to evaluate microsatellite instability in cervical cancer. Altogether 80 paired cervical cancers were studied. Our results sh owed that microsatellite instability is not common in cervical cancer, and the mutation of the single base repeat of mismatch repair (MMR) genes (hMSH 3 and hMSH6) is also uncommon, The BAT-26 is not a good marker to detect th e RER status of cervical cancer.