Cholesterol and triglyceride reduction in rats fed Matthiola incana seed oil rich in (n-3) fatty acids

Seeds of Matthiola incana contain oil rich (55-65%) in (n-3) linolenic acid . Selected lines were developed and evaluated for their agronomic and chemi cal parameters. Extracted oil was fed for 6 weeks to rats, which were compa red with rats fed a diet containing coconut oil or sunflower oil. Cholester ol levels were significantly lowest in rats fed diets rich in M. incana oil (27% reduction), and triglycerides were significantly lower in rats receiv ing either M. incana or sunflower oil (36% reduction). The contents of arac hidonic acid and other (n-6) fatty acids were significantly the lowest in t he liver and plasma of rats that had received M. incana oil. The levels of( n-3) fatty acids were significantly greater in both the liver and plasma of rats fed M. incana oil. The ratio of(n-3)/(n-6) long-chain fatty acids in the plasma was 7 times higher in rats fed with M. incana oil than in those fed with sunflower oil and 6 times higher than in those fed coconut oil. Th e results demonstrate for the first time a beneficial effect of dietary M. incana oil in reducing cholesterol levels and increasing (n-3) fatty acid l evels in the plasma. This new, terrestrial plant source of (n-3) fatty acid s could replace marine oils and thereby contribute beneficially to the huma n diet.