A general multilocus two-allele model for epistatic selection

Observations show that evolutionary processes often relate to multilocus ep istatic selection. Here we develop further the approach suggested earlier b y Zhivotovsky and Gavrilets to admit arbitrary multilocus epistasis. The ob tained dynamic equations for allelic frequencies and gametic disequilibria are represented in a simple form. If selection is weak, this result extends Wright's evolutionary equation to the case of cia-trans effects and sex di fferences in both recombination rates and genotypic fitnesses. Additionally to Wright's equations for allelic frequencies, we derive equations for the gametic disequilibrium terms. We also give a general expression for the,ga metic disequilibria in a quasi-linkage state.