Based on its biomass, Diporeia spp. represent the major benthic invertebrat
e in offshore waters of the Great Lakes. This work reviews the recent findi
ngs of factors influencing the organism with particular focus on interpreti
ng the potential for contaminant stress, with an emphasis on organic contam
inants, and the benthic pelagic link for contaminant food web transfer. The
review includes examination of the environmental features that limit the d
istribution and population density. The physiology of Diporeia spp., includ
ing energy storage, respiration, and nutrient elimination, are discussed. T
he toxicokinetics from both aqueous and sediment exposures are reviewed, as
well as both the environmental factors that influence the kinetics and the
limitations to our knowledge. The interactions of the physiology and toxic
okinetics are presented for interpretation of toxic responses and the sensi
tivity of the organism to selected contaminants. Finally, this review sugge
sts areas where increased information is needed to improve our understandin
g of Diporeia toxicokinetics and toxicity In the Great Lakes environment.