Hydrophobicity parameters determined by reversed-phase liquid chromatography for some new isoxazolyl-naphthoquinones

The lipophilic character of a series of new isoxazolylnaphthoquinones has b een studied. Partition chromatography procedures (RP-HPLC and RP-TLC) were developed for determining the log Po-w (n-octanol/water partition coefficie nt) values. The experimental values from these methods were validated by co mparison with those obtained from the conventional shake flask method, exce pt with the more lipophilic 4, 6 and 7 because they have poor water solubil ity. Also, the log Po-w was calculated using a CLOGP computer programme.