Dermorphin and deltorphin glycosylated analogues: Synthesis and antinociceptive activity after systemic administration

In the present paper we describe the synthesis of some dermorphin and delto rphin analogues beta-O- and alpha-C-glycosylated on the C-terminal amino ac id residue and report their opioid receptor affinity and selectivity as wel l as their analgesic potency after subcutaneous injection in mice.