G. Cinalli et al., Sylvian aqueduct syndrome and global rostral midbrain dysfunction associated with shunt malfunction, J NEUROSURG, 90(2), 1999, pp. 227-236
Object. This study is a retrospective analysis of clinical data obtained in
28 patients affected by obstructive hydrocephalus who presented with signs
of midbrain dysfunction during episodes of shunt malfunction.
Methods. All patients presented with an upward gaze palsy, sometimes associ
ated with other signs of oculomotor dysfunction. In seven cases the ocular
signs remained isolated and resolved rapidly after shunt revision. In 21 ca
ses the ocular signs were variably associated with other clinical manifesta
tions such as pyramidal and extrapyramidal deficits, memory disturbances, m
utism, or alterations in consciousness. Resolution of these symptoms after
shunt revision was usually slow. In four cases a transient paradoxical aggr
avation was observed at the time of shunt revision. In 11 cases ventriculoc
isternostomy allowed resolution of the symptoms and withdrawal of the shunt
.
Simultaneous supratentorial and infratentorial intracranial pressure record
ings performed in seven of the patients showed a pressure gradient between
the supratentorial and infratentorial compartments, with a higher supratent
orial pressure before shunt revision. In version of this pressure gradient
was observed after shunt revision and resolution of the gradient was observ
ed in one case after third ventriculostomy. In six recent cases, a focal mi
dbrain hyperintensity was evidenced on T-2-weighted magnetic resonance imag
ing sequences at the time of shunt malfunction. This rapidly resolved after
the patient underwent third ventriculostomy.
Conclusions. It is probable that in obstructive hydrocephalus, at the time
of shunt malfunction, the development of a transtentorial pressure gradient
could initially induce a functional impairment of the upper midbrain, indu
cing upward gaze palsy. The persistence of the gradient could lead to a glo
bal dysfunction of the upper midbrain. Third ventriculostomy contributes to
equalization of cerebrospinal fluid pressure across the tentorium by resto
ring free communication between the infratentorial and supratentorial compa
rtments, resulting in resolution of the patient's clinical symptoms.