NUCLEOCYTOPLASMIC TRANSPORT - SIGNALS, MECHANISMS AND REGULATION

In eukaryotic organisms, DNA replication and RNA biogenesis occur in t he cell nucleus, whereas protein synthesis occurs in the cytoplasm. In tegration of these activities depends on selective transport of protei ns and ribonucleoprotein particles between the two compartments. Trans port across the nuclear envelope occurs through large multiprotein str uctures, termed nuclear pore complexes. It is signal-mediated and requ ires both energy and soluble factors, including shuttling carriers. He re I summarize current understanding of nucleocytoplasmic transport an d illustrate the importance of regulated transport for signal transduc tion.