Assessments of the regional impacts of human-induced climate change on a wi
de range of social and environmental systems are fundamental for determinin
g the appropriate policy responses to climate change(1-3). Yet regional-sca
le impact assessments are fraught with difficulties, such as the uncertaint
ies of regional climate-change prediction(4), the specification of appropri
ate environmental-response models(5), and the interpretation of impact resu
lts in the context of future socio-economic and technological change(6). Th
e effects of such confounding factors on estimates of climate-change impact
s have only been poorly explored(3-7). Here we use results from recent glob
al climate simulations(8) and two environmental response models(9,10) to co
nsider systematically the effects of natural climate variability (30-year t
imescales) and future climate-change uncertainties on river runoff and agri
cultural potential in Europe. We find that, for some regions, the impacts o
f human-induced climate change by 2050 will be undetectable relative to tho
se due to natural multi-decadal climate variability. If misleading assessme
nts of-and inappropriate adaptation strategies to-climate-change impacts ar
e to be avoided, future studies should consider the impacts of natural mult
idecadal climate variability alongside those of human-induced climate chang
e.