On the possible use of a new boron compound, hydroxysalicylhydroxamato boron(III), and ultrasound in the treatment of female mice bearing the Ehrlichascites carcinoma cells

The inhibitory effects of a new boron compound hydroxy salicylhydroxamato b oron (III) (SHB) and ultrasound of frequency 25 KHz (US) on the growth of a scites tumor in female Swiss mice were studied by monitoring the survival a nd the tumor growth in the treated tumor bearing mice and also the transpla ntability and the DNA synthesis in the treated tumor (Ehrlich ascites carci noma) cells. While SHB alone produced a highly significant antitumor activi ty, US alone produced a small but significant effect. The combination of SH B and US produced significantly greater antitumor activity than SHB alone. The mechanisms of SHB and US actionary are discussed.